Toxicological risk assessment contributing to reduced animal testing.

Predictive toxicology using in silico tools are becoming increasingly important in order to gain time and efficiency in the development of a substance or in the risk assessment before market access. The use of the in silico QSAR approach is encouraged by the REACH regulation 1907/2006/EC and COSMETICS regulation 1223/2009/EC.

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Predictive Toxicology : QSAR based methodology

🔹 Our models are in line with the OECD principles for the QSAR validation, namely :

A well defined category of toxicity
An unambiguous algorithm
A well defined domain of applicability
Statistical criteria about performance

🔹 Today, our Safety By Design approach consists of nine QSAR based statistical models to predict:

Acute toxicity
Carcinogenicity
Mutagenicity
Neurotoxicity
Reprotoxicity
Endocrine disruption
Persistent, bioaccumulative and toxic (PBT) behavior
Respiratory sensitization
Eco-toxicity

🔹 It applies to impurities from the synthesis of pharmaceutical compounds, to your new cosmetic ingredients and botanical extracts, and to specialty chemistry compounds:

A study report allows a categorization of your compounds according to the selected toxicities endpoints required to comply with current regulations and facilitate the commercialization of your product.

Getting benefits right away

✔️ GENERATE TOXICTY ALERTS AT EARLY STAGE

Toxicty alerts could be generated at any stage of a compound development for any of the 9 toxicity endpoints (simultaneously or separately).

✔️ GUIDE IN VITRO & IN VIVO ASSAYS

The data generated as a result of our in silico assessments guide you to select the relevant experimental validations in case of a toxicity alert in line with OECD guidelines.

✔️ COMPLY WITH THE REGULATIONS

The data generated as a result of our in silico assessments contribute to the compliance with the REACH and COSMETICS regulations.

A straightforward rate

	Price per compound (excluding VAT)



EVALUATION ON 9 QSAR MODELSAcute toxicity Carcinogenicity Mutagenicity Neurotoxicity Reprotoxicity Endocrine disruption Persistent, bioaccumulative and toxic (PBT) behavior Respiratory sensitization Eco-toxicity	9 000€
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Decision making support

We provide you with a tailor-made support to add value of your products.

How does it work?

You send us the chemical structure of your molecules.

We just need the 2D structure of your molecule to be processed.

We calculate chemical descriptors from the structure.

Your molecule is then described with an ensemble of significant descriptors.

We generate a toxicity profile with the QSAR models of your choice.

We processed the molecule using our QSAR models which allows to generate a toxicity alerts.

You validate the predicted toxicity endpoints by appropriate experimental tests.

You get a detailed report on your molecule of interest that helps you choose in vitro and in vivo experimental tests and fill out the safety data sheet for regulatory submission.